science (5)

A Path From Panic...

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PAC1R-expressing dorsal raphe neurons in the mouse brain (red) serve as the projection targets for PACAP parabrachial neurons to mediate panic-like behavioral and physical symptoms. Credit: Salk Institute

Topics: Biology, Medicine, Research, Science

Overwhelming fear, sweaty palms, shortness of breath, rapid heart rate—these are the symptoms of a panic attack, which people with panic disorder have frequently and unexpectedly. Creating a map of the regions, neurons, and connections in the brain that mediate these panic attacks can provide guidance for developing more effective panic disorder therapeutics.

Now, Salk researchers have begun to construct that map by discovering a brain circuit that mediates panic disorder. This circuit consists of specialized neurons that send and receive a neuropeptide—a small protein that sends messages throughout the brain—called PACAP. What's more, they determined that PACAP and the neurons that produce its receptor are possible druggable targets for new panic disorder treatments.

The findings were published in Nature Neuroscience.

"We've been exploring different areas of the brain to understand where panic attacks start," says senior author Sung Han, associate professor at Salk.

"Previously, we thought the amygdala, known as the brain's fear center, was mainly responsible—but even people who have damage to their amygdala can still experience panic attacks, so we knew we needed to look elsewhere. Now, we've found a specific brain circuit outside of the amygdala that is linked to panic attacks and could inspire new panic disorder treatments that differ from currently available panic disorder medications that typically target the brain's serotonin system."

Scientists uncover key brain pathway mediating panic disorder symptoms, Salk Institute.

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The Decline of Disruptive Science…

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The proportion of disruptive scientific papers, such as the 1953 description of DNA’s double-helix structure, has fallen since the mid-1940s.Credit: Lawrence Lawry/SPL

Topics: DNA, Education, Philosophy, Research, Science, STEM

The number of science and technology research papers published has skyrocketed over the past few decades — but the ‘disruptiveness’ of those papers has dropped, according to an analysis of how radically papers depart from the previous literature1.

Data from millions of manuscripts show that, compared with the mid-twentieth century, research done in the 2000s was much more likely to incrementally push science forward than to veer off in a new direction and render previous work obsolete. Analysis of patents from 1976 to 2010 showed the same trend.

“The data suggest something is changing,” says Russell Funk, a sociologist at the University of Minnesota in Minneapolis and a co-author of the analysis published on 4 January in Nature. “You don’t have quite the same intensity of breakthrough discoveries you once had.”

Telltale citations

The authors reasoned that if a study were highly disruptive, subsequent research would be less likely to cite its references and instead cite the study itself. Using the citation data from 45 million manuscripts and 3.9 million patents, the researchers calculated a measure of disruptiveness called the ‘CD index,’ in which values ranged from –1 for the least disruptive work to 1 for the most disruptive.

The average CD index declined by more than 90% between 1945 and 2010 for research manuscripts (see ‘Disruptive science dwindles’) and more than 78% from 1980 to 2010 for patents. Disruptiveness declined in all analyzed research fields and patent types, even when factoring in potential differences in factors such as citation practices.

‘Disruptive’ science has declined — and no one knows why, Max Kozlov, Nature.

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Well Deserved...

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Anthony Fauci has advised seven presidents on public health, most recently serving as chief medical advisor to President Joe Biden. | NIAID

 

Topics: Biology, COVID-19, Research, Science

 

Anthony Fauci – Director of the National Institute of Allergy and Infectious Diseases, an expert on HIV and immunoregulation, and the de facto public face of a science-based recovery from COVID-19 – has been named the winner of the 2021 Philip Hauge Abelson Prize, awarded annually by the American Association for the Advancement of Science to a scientist or public servant who has contributed significantly to the advancement of science in the United States.

 

Fauci is “an outstanding scientist with more than a thousand publications” and “an exceptional public servant, having been at the forefront of the world’s efforts to combat diverse infectious diseases for over 40 years,” wrote Alan Leshner, former chief executive officer of AAAS, in nominating Fauci for the prize. The prize committee cited Fauci’s “extraordinary contributions to science and medicine” and his service that has shaped research and public policy.

 

Anthony Fauci to Receive 2021 AAAS Abelson Prize, Andrea Korte, American Association for the Advancement of Science

 

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The Path Forward...

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Topics: Climate Change, COVID-19, Existentialism, Science

Science, as Carl Sagan wrote, has to be our "candle in the dark."

The Scientific Method we developed as a hunter-gatherer species. The tools of hunter-gatherers were utilitarian and pragmatic. Our ancestors observed things and noticed patterns. They made mental notes of these patterns and codified them through rituals, customs, and behaviors into distinct cultures defined by these traditions. Some kept this knowledge in secret, esoteric, as any knowledge is power over others. This probably is the reason why we're so suspicious of any change in what was, or is new knowledge.

Many first-responders are BIPOC, so the resistance to it, probably from the apprehension around the Tuskegee Experiment, has an understandable history, but it's still alarming. We can wear masks. We can contact trace. We can socially distance. We can take the Pfizer, Moderna, or AstraZeneca variants of the vaccine, and mitigate this more quickly.

Or, we can guarantee after a long dark winter, a long slog through the spring, summer, and fall. Herd immunity isn't by brute force: it is intentionally engineered with vaccines.

WASHINGTON — Authorities are reporting early shipments of the COVID 19 vaccine will not cover all essential personnel who are supposed to be first in line to get it. The CDC's immunization advisory panel voted Tuesday to give the first round of COVID-19 vaccines to health care personnel and long-term care facility residents.

Hundreds of thousands of frontline medical workers are at the top of that list. But surveys are showing that not all are eager to be first.

While 63% of health care workers reported to the U.S. Centers for Disease Control that they would accept the vaccine, the agency is concerned about the large numbers who are hesitant. The American Nurses Foundation is reporting 36% of nurses surveyed said they would not voluntarily get the COVID-19 vaccine once it's deployed.

'No one wants to be a guinea pig' | Vaccine hesitancy divides health care workers, Scott Broom, ABC10 News

Carbon sequestration involves a lot of technology, or it can involve what Earth did before we discovered technology: plant more trees.

Forty-nine million years ago, a small aquatic fern called Azolla wrested control of Earth’s climate. At the time, the landlocked Arctic Ocean developed a surface layer of fresh water, which allowed the ferns to grow unchecked in a wide-open environment. Billions of tons of plants died and sank to the bottom of the ocean, taking with them the carbon they had sucked from the air when they were alive. 

The consequences were extreme. Geologic evidence indicates that atmospheric carbon dioxide levels plummeted more than 80 percent over 800,000 years, sharply ratcheting down Earth’s thermostat. Prior to the inferred “Azolla Event,” most of the globe was lush and tropical. Afterward, the Arctic cooled by nearly 40 degrees Fahrenheit, the poles froze, and our planet entered a lurching cycle of ice ages that continues to this day. 

How to Bury Carbon? Let Plants Do the Dirty Work, Cory S. Powell, Cold Springs Harbor Laboratory

This seems simple enough, but politicians like Jair Bolsonaro apparently came to power much like our one-term Neo-fascist did: lifted to the office by right-wing Christian zealots in Brazil, particularly of the megachurch kind. From a dominionist view, carbon sequestration shows a "lack of faith." Forty-nine million years ago is a long way from a mere guestimate of ten-thousand years. Burning the Amazon, like for many cheering for Armageddon hastens the Apocalypse, and the Second Coming. It is thus, anathema.

I follow Politics and Prose on YouTube. David K. Johnston gave a speech at their bookstore some time ago on his book: "The Making of Donald Trump." Many things weren't a revelation to me, but one thing, in particular, stuck with me.

People the world over are afraid. Con artists, fascists, and strongmen play on fear.

I'm talking pre-pandemic afraid: afraid of change, afraid of diversity, afraid their particular sacred texts do not line up neatly with new scientific discoveries; afraid of their traditions being challenged in the light of Sagan's candle. Such fear gives political power to strongmen (the antonym more accurate) that assure their crowds on their rise to power that they will return those fearful of change to a "golden age of greatness," which they never really define. The other common thing is there is a scapegoated "other" on which all blame for everything wrong is laid. That is the history of the scapegoat, by the way. For humans, it leads to disdain, disregard, murder, and genocide.

For an otherwise intelligent species, that can lead to extinction.

A preprint paper in ArXiv gives the grim estimate that intelligent species over long stretches of time eventually annihilate themselves. I would really like us all to be the rare exceptions to this possible rule.

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Eratosthenes to Starfish...

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Sir Isaac Newton's impact on Optics. Link below.


Topics: Geometry, History, Science, Research


Every day, we conduct science experiments, posing an “if” with a “then” and seeing what shakes out. Maybe it’s just taking a slightly different route on our commute home or heating that burrito for a few seconds longer in the microwave. Or it could be trying one more variation of that gene, or wondering what kind of code would best fit a given problem. Ultimately, this striving, questioning spirit is at the root of our ability to discover anything at all. A willingness to experiment has helped us delve deeper into the nature of reality through the pursuit we call science.

A select batch of these science experiments has stood the test of time in showcasing our species at its inquiring, intelligent best. Whether elegant or crude, and often with a touch of serendipity, these singular efforts have delivered insights that changed our view of ourselves or the universe.

Here are nine such successful endeavors — plus a glorious failure — that could be hailed as the top science experiments of all time.

Eratosthenes Measures the World

Experimental result: The first recorded measurement of Earth’s circumference
 

When: end of the third century B.C.

Just how big is our world? Of the many answers from ancient cultures, a stunningly accurate value calculated by Eratosthenes has echoed down the ages. Born around 276 B.C. in Cyrene, a Greek settlement on the coast of modern-day Libya, Eratosthenes became a voracious scholar — a trait that brought him both critics and admirers. The haters nicknamed him Beta, after the second letter of the Greek alphabet. University of Puget Sound physics professor James Evans explains the Classical-style burn: “Eratosthenes moved so often from one field to another that his contemporaries thought of him as only second-best in each of them.” Those who instead celebrated the multi-talented Eratosthenes dubbed him Pentathlos, after the five-event athletic competition.

That mental dexterity landed the scholar a gig as chief librarian at the famous library in Alexandria, Egypt. It was there that he conducted his famous experiment. He had heard of a well in Syene, a Nile River city to the south (modern-day Aswan), where the noon sun shone straight down, casting no shadows, on the date of the Northern Hemisphere’s summer solstice. Intrigued, Eratosthenes measured the shadow cast by a vertical stick in Alexandria on this same day and time. He determined the angle of the sun’s light there to be 7.2 degrees, or 1/50th of a circle’s 360 degrees.

Knowing — as many educated Greeks did — Earth was spherical, Eratosthenes fathomed that if he knew the distance between the two cities, he could multiply that figure by 50 and gauge Earth’s curvature, and hence its total circumference. Supplied with that information, Eratosthenes deduced Earth’s circumference as 250,000 stades, a Hellenistic unit of length equaling roughly 600 feet. The span equates to about 28,500 miles, well within the ballpark of the correct figure of 24,900 miles.

Eratosthenes’ motive for getting Earth’s size right was his keenness for geography, a field whose name he coined. Fittingly, modernity has bestowed upon him one more nickname: father of geography. Not bad for a guy once dismissed as second-rate.

 

The Top 10 Science Experiments of All Time, Adam Hadhazy, Discover Magazine

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