BLOGS

NIST researcher Megan Cleveland uses a PCR machine to amplify DNA sequences by copying them numerous times through a series of chemical reactions.
Credit: M. Cleveland/NIST

Topics: Biology, Biotechnology, COVID-19, Diversity in Science, NIST, Research, Women in Science

Scientists track and monitor the circulation of SARS-CoV-2, the virus that causes COVID-19, using methods based on a laboratory technique called polymerase chain reaction (PCR). Also used as the “gold standard” test to diagnose COVID-19 in individuals, PCR amplifies pieces of DNA by copying them numerous times through a series of chemical reactions. The number of cycles it takes to amplify DNA sequences of interest so that they are detectable by the PCR machine, known as the cycle threshold (Ct), is what researchers and medical professionals look at to detect the virus.

However, not all labs get the same Ct values (sometimes also called “Cq” values). In efforts to make the results more comparable between labs, the National Institute of Standards and Technology (NIST) contributed to a multiorganizational study that looked at anchoring these Ct values to a reference sample with known amounts of the virus.

Researchers published their findings in the journal PLOS One.

SARS-CoV-2 is an RNA virus: Its genetic material is single-stranded instead of double-stranded like DNA and contains some different molecular building blocks, namely uracil in place of thymine. But the PCR test only works with DNA, and labs first must convert the RNA to DNA to screen for COVID-19. For the test, RNA is isolated from a patient’s sample and combined with other ingredients, including short DNA sequences are known as primers, to transform the RNA into DNA.

RNA Reference Materials Are Useful for Standardizing COVID-19 Tests, Study Shows, NIST

Reflective markers are attached to blue 3D-printed apparatus above and below the user’s knee as well as two metal plates on the exoskeleton leg. Researchers track and compare the movement of the markers to gain insight into how well the exoskeletons fit. In this composite photo, the bottom plate has been added after the original image was taken to show the entire configuration.
Credit: N. Hanacek/NIST

Topics: Applied Physics, NIST, Research, Robotics

A shoddily tailored suit or a shrunken T-shirt may not be the most stylish, but wearing them is unlikely to hurt more than your reputation. An ill-fitting robotic exoskeleton on the battlefield or factory floor, however, could be a much bigger problem than a fashion faux pas. 

Exoskeletons, many of which are powered by springs or motors, can cause pain or injury if their joints are not aligned with the user. To help manufacturers and consumers mitigate these risks, researchers at the National Institute of Standards and Technology (NIST) developed a new measurement method to test whether an exoskeleton and the person wearing it are moving smoothly and in harmony. 

In a new report, the researchers describe an optical tracking system (OTS) not unlike the motion capture techniques used by filmmakers to bring computer-generated characters to life. 

The OTS uses special cameras that emit light and capture what is reflected back by spherical markers arranged on objects of interest. A computer calculates the position of the labeled objects in 3D space. Here, this approach was used to track the movement of an exoskeleton and test pieces, called “artifacts,” fastened to its user.

Exoskeleton Research Marches Forward With NIST Study on Fit, NIST

This artist’s conception of threshold cryptography shows a lock that can only be opened by three people working together. When the threshold cryptosystem receives a request to process information with a secret key, it initially splits the key into shares and sends them to the entire group, each share to a different participant. The three people must agree to work together and also perform their own secret operations on the incoming message. From these actions, each person uses their share key — represented by the three colored circles — to process the message, and then sends the result back to the system. Only the combination of all three partial results can open the lock, reducing the likelihood that a single corrupt party could compromise the system.

Topics: Cryptography, Computer Science, Electrical Engineering, NIST

A new publication by cryptography experts at the National Institute of Standards and Technology (NIST) proposes the direction the technical agency will take to develop a more secure approach to encryption. This approach, called threshold cryptography, could overcome some of the limitations of conventional methods for protecting sensitive transactions and data.

The document, released today in a final version as NIST Roadmap Toward Criteria for Threshold Schemes for Cryptographic Primitives (NISTIR 8214A), offers an outline for developing a new way to implement the cryptographic tools that developers use to secure their systems. Its authors are inviting the cryptography community to collaborate with them on NIST’s budding Threshold Cryptography project, which in part seeks to ensure that threshold implementations are interoperable.

“We are kicking the threshold cryptography development effort into high gear,” said Apostol Vassilev, a NIST computer scientist. “Over the coming months, the Threshold Cryptography project will be engaging with the public to define criteria for this work. We want to get feedback from the community so we can consider a variety of threshold schemes and standardization paths.”

Threshold cryptography takes its name from the idea that individual keyholders cannot open a lock on their own, as is common in conventional cryptography. Instead, out of a group of keyholders, there must be a minimum number of them — a “threshold” number — working together to open the lock. In practice, this lock is an electronic cryptosystem that protects confidential information, such as a bank account number or an authorization to transfer money from that account.

NIST Kick-Starts ‘Threshold Cryptography’ Development Effort

Credit: N. Hanacek/NIST NIST evaluated several commercially available contactless fingerprint scanning technologies in its May 2020 report.

Topics: NIST, Optics, Research

The National Institute of Standards and Technology (NIST) has evaluated several commercially available contactless fingerprint scanning technologies, allowing users to compare their performance to conventional devices that require physical contact between a person’s fingers and the scanner.

The results of the study, published today as NIST Interagency Report (NISTIR) 8307: Interoperability Assessment 2019: Contactless-to-Contact Fingerprint Capture, show that devices requiring physical contact remain superior to contactless technology at matching scanned prints to images in a database. However, when contactless devices scan multiple fingers on a hand, it improves their performance. Contactless devices that scanned multiple fingers also seldom made “false positive” errors that incorrectly matched one person’s print with another’s record.

The publication updates NIST’s July 2018 study on contactless capture and is intended to assist organizations that use fingerprint-scanning technology.

“The report summarizes the state of the art of contactless fingerprint scanning,” said John Libert, one of the report’s authors. “It can help anyone interested in adopting contactless technology to evaluate the cost in performance they might pay by switching to contactless fingerprint capture.”

NIST Study Measures Performance Accuracy of Contactless Fingerprinting Tech

Image source: "Dunamis Novem" link below

Topics: NIST, Quantum Mechanics, Research, STEAM

What is Quantum Physics? Dancers Explain, NIST
Sam Mitchel Dance: Dunamis Novem

Physics World: A brief history of timekeeping

Topics: Atomic Physics, Laser, NIST, Quantum Mechanics, Research

Entangled aluminum ion is world’s best timekeeper, Edwin Cartlidge, Physics World