BLOGS

1 Soap, shampoo, and worm-like micelles Soaps and shampoos are made from amphiphilic molecules with water-loving (red) and water-hating (blue) parts that arrange themselves to form long tubes known as “worm-like micelles”. Entanglements between the tubes give these materials their pleasant, sticky feel. b The micelles can, however, disentangle themselves, just as entangled long-chain polymer molecules can slide apart too. In polymers, this process can be modeled by imagining the molecule sliding, like a snake, out of an imaginary tube formed by the surrounding spatial constraints. c Worm-like micelles can also morph their architecture by performing reconnections (left), breakages (down), and fusions (right). These operations occur randomly along the backbone, are in thermal equilibrium, and are reversible. (Courtesy: Davide Michieletto)

Topics: Biology, Biotechnology, DNA, Molecules

DNA molecules are not fixed objects – they are constantly getting broken up and glued back together to adopt new shapes. Davide Michieletto explains how this process can be harnessed to create a new generation of “topologically active” materials.

Call me naive, but until a few years ago I had never realized you can actually buy DNA. As a physicist, I’d been familiar with DNA as the “molecule of life” – something that carries genetic information and allows complex organisms, such as you and me, to be created. But I was surprised to find that biotech firms purify DNA from viruses and will ship concentrated solutions in the post. In fact, you can just go online and order DNA, which is exactly what I did. Only there was another surprise in store.

When the DNA solution arrived at my lab in Edinburgh, it came in a tube with about half a milligram of DNA per centimeter cube of water. Keen to experiment with it, I tried to pipette some of the solutions out, but they didn’t run freely into my plastic tube. Instead, it was all gloopy and resisted the suction of my pipette. I rushed over to a colleague in my lab, eagerly announcing my amazing “discovery”. They just looked at me like I was an idiot. Of course, solutions of DNA are gloopy.

I should have known better. It’s easy to idealize DNA as some kind of magic material, but it’s essentially just a long-chain double-helical polymer consisting of four different types of monomers – the nucleotides A, T, C, and G, which stack together into base pairs. And like all polymers at high concentrations, the DNA chains can get entangled. In fact, they get so tied up that a single human cell can have up to 2 m of DNA crammed into an object just 10 μm in size. Scaled up, it’s like storing 20 km of hair-thin wire in a box no bigger than your mobile phone.

Make or break: building soft materials with DNA, Davide Michieletto is a Royal Society university research fellow in the School of Physics and Astronomy, University of Edinburgh, UK

A nurse prepares a COVID-19 vaccine in Guwahati, India, on 10 April. A new subvariant named BA.2.75 that was first detected in India has surfaced in many other countries. ANUPAM NATH/AP IMAGES

Topics: Biology, COVID-19, DNA, Economics, Environment, Evolution, Existentialism

Ed Rybicki, a virologist at the University of Cape Town in South Africa, concentrated his article in Scientific American on the viruses dominating the news cycle in the early 2000s: Ebola, Marburg, and HIV. Not comforting, but he said, "HIV, which is thought to have first emerged in humans in the 1930s, is another kind of virus, known as a retrovirus." Not mentioned, but the H1N1 comes from the 1918 Flu Pandemic, and a friend in Texas lost his girlfriend to it also in the early 2000s. Retro means "a process that reverses the normal flow of information in cells" and relates to a bridge between the first forms of life on this planet. In an e-brief, I wrote my first year at JSNN, an article in Nature: Education posits that viruses are not ‘alive’ because they don’t have metabolic processes, one of the four criteria for life (“organized, metabolism, genetic code, and reproduction”). The last part is important: they cannot reproduce asexually (unicellular division), or sexually with genders, spermatozoa, and an incubation period before birthing a copy. In other words, they aren't "alive," but they aren't dead either. They manage to replicate themselves by invading a host. Usually us.

It DOES mention three possible mechanisms as to origins: The Progressive Hypothesis, i.e., “bits and pieces” of a genome gained the ability to move in and out of cells (retroviruses like HIV given as an example); The Regressive Hypothesis, meaning the viruses evolved from some common ancestor to their current state (reductio ad absurdum), lastly The Virus-First Hypothesis, which puts any anthropocentric notions away and their hypothesis that viruses existed before mortals as “self-replicating units.”

I am as ready for this pandemic to be over as anyone else. However, this read from AAAS didn't give me hope that a societal "all-clear" will be uttered, or that we'll overcome our shared arrogance and stupidity:

In the short history of the COVID-19 pandemic, 2021 was the year of the new variants. Alpha, Beta, Gamma, and Delta each had a couple of months in the Sun.

But this was the year of Omicron, which swept the globe late in 2021 and has continued to dominate, with subvariants—given more prosaic names such as BA.1, BA.2, and BA.2.12.1—appearing in rapid succession. Two closely related subvariants named BA.4 and BA.5 are now driving infections around the world, but new candidates, including one named BA.2.75, are knocking on the door.

Omicron’s lasting dominance has evolutionary biologists wondering what comes next. Some think it’s a sign that SARS-CoV-2’s initial frenzy of evolution is over and it, like other coronaviruses that have been with humanity much longer, is settling into a pattern of gradual evolution. “I think a good guess is that either BA.2 or BA.5 will spawn additional descendants with more mutations and that one or more of those subvariants will spread and will be the next thing,” says Jesse Bloom, an evolutionary biologist at the Fred Hutchinson Cancer Research Center.

But others believe a new variant different enough from Omicron and all other variants to deserve the next Greek letter designation, Pi, may already be developing, perhaps in a chronically infected patient. And even if Omicron is not replaced, its dominance is no cause for complacency, says Maria Van Kerkhove, technical lead for COVID-19 at the World Health Organization. “It’s bad enough as it is,” she says. “If we can’t get people to act [without] a new Greek name, that’s a problem.”

As Omicron rages on, scientists have no idea what comes next, Kai Kupferschmidt, American Association for the Advancement of Science

Credit: Gao Wang

Topics: Biology, Cancer, Chemotherapy, Robotics

Chemotherapy disrupts cancer cells’ ability to reproduce by frustrating cell division and damaging the cells’ DNA. In response to the pharmaceutical onslaught, cancer cells acquire mutations that reduce the therapy’s effectiveness. Compounding the challenge of fighting cancer: Under chemical and other stresses, mutation rates increase.

A team led by Princeton University’s Robert Austin and Chongqing University’s Liyu Liu has developed a novel approach to study—and potentially thwart—cancer cells’ adaptation to chemotherapy. Their cancer cell analogs are wheeled, cylindrical robots about 65 mm in diameter and 60 mm in height (see photo above). Fifty of the robots roll independently of each other over a square table, whose 4.2 × 4.2 m² surface is covered by 2.7 million LEDs (see photo below). Light from the LEDs serves as the robots’ food. Once a robot has “eaten” the light beneath it, the corresponding LEDs are dimmed until they recover a fixed time later.

The bottom surface of each robot is equipped with four semiconductor-based sensors that can detect the intensities and spatial gradients of the three colors of light emitted by the light table: red, green, and blue (RGB). Each robot’s six-byte genome analog determines how sensitive it is to the three colors. The sensitivity, in turn, determines how readily the robot moves in response to the colors’ intensities and spatial gradients.

Evolving robots could optimize chemotherapy, Charles Day, Physics Today

Image Source: Hub Pages

Topics: Biology, Civics, Civil Rights, Climate Change, Democracy, Existentialism, Politics

The cornucopia’s history lies in Greek mythology. There are a lot of different stories it might have originated from, but the most common one tells the story of the lightning god, Zeus. As an infant, Zeus was in great danger from his father, Cronus. Zeus was taken to the island of Crete and cared for and nursed by a goat named Amalthea. One day, he accidentally broke off one of her horns, and in order to repay her, he used his powers to ensure that the horn would be a symbol of eternal nourishment, which is where we get the idea that the cornucopia represents abundance.

The History Behind the “Horn of Plenty”, Winnie Lam, Daily Nexus

*****

Russia’s war highlights the fragility of the global food supply — sustained investment is needed to feed the world in a changing climate.

Six boxes of wheat seed sit in our cold store. This is the first time in a decade that my team has not been able to send to Ukraine the improved germplasm we’ve developed as part of the Global Wheat Program at the International Maize and Wheat Improvement Center in Texcoco, Mexico. International postal and courier services are suspended. The seed had boosted productivity year on year in the country, which is now being devastated by war.

Our work builds on the legacy of Norman Borlaug, who catalyzed the Green Revolution and staved off famine in South Asia in the 1970s. Thanks to him, I see how a grain of wheat can affect the world.

Among the horrifying humanitarian consequences of Russia’s invasion of Ukraine are deeply troubling short-, medium- and long-term disruptions to the global food supply. Ukraine and Russia contribute nearly one-third of all wheat exports (as well as almost one-third of the world’s barley and one-fifth of its corn, providing an estimated 11% of the world’s calories). Lebanon, for instance, gets 80% of its wheat from Ukraine alone.

Broken bread — avert global wheat crisis caused by invasion of Ukraine, Alison Bentley, Nature

Plastic fantastic: this perovskite-based device can be reconfigured and could play an important role in artificial intelligence systems. (Courtesy: Purdue University/Rebecca McElhoe)

Topics: Artificial Intelligence, Biology, Computer Science, Materials Science

Researchers in the US have developed a perovskite-based device that could be used to create a high-plasticity architecture for artificial intelligence. The team, led by Shriram Ramanathan at Purdue University, has shown that the material’s electronic properties can be easily reconfigured, allowing the devices to function like artificial neurons and other components. Their results could lead to more flexible artificial-intelligence hardware that could learn much like the brain.

Artificial intelligence systems can be trained to perform a task such as voice recognition using real-world data. Today this is usually done in software, which can adapt when additional training data are provided. However, machine learning systems that are based on hardware are much more efficient and researchers have already created electronic circuits that behave like artificial neurons and synapses.

However, unlike the circuits in our brains, these electronics are not able to reconfigure themselves when presented with new training information. What is needed is a system with high plasticity, which can alter its architecture to respond efficiently to new information.

Device can transform into four components for artificial intelligence systems, Sam Jarman, Physics World

NIST researcher Megan Cleveland uses a PCR machine to amplify DNA sequences by copying them numerous times through a series of chemical reactions.
Credit: M. Cleveland/NIST

Topics: Biology, Biotechnology, COVID-19, Diversity in Science, NIST, Research, Women in Science

Scientists track and monitor the circulation of SARS-CoV-2, the virus that causes COVID-19, using methods based on a laboratory technique called polymerase chain reaction (PCR). Also used as the “gold standard” test to diagnose COVID-19 in individuals, PCR amplifies pieces of DNA by copying them numerous times through a series of chemical reactions. The number of cycles it takes to amplify DNA sequences of interest so that they are detectable by the PCR machine, known as the cycle threshold (Ct), is what researchers and medical professionals look at to detect the virus.

However, not all labs get the same Ct values (sometimes also called “Cq” values). In efforts to make the results more comparable between labs, the National Institute of Standards and Technology (NIST) contributed to a multiorganizational study that looked at anchoring these Ct values to a reference sample with known amounts of the virus.

Researchers published their findings in the journal PLOS One.

SARS-CoV-2 is an RNA virus: Its genetic material is single-stranded instead of double-stranded like DNA and contains some different molecular building blocks, namely uracil in place of thymine. But the PCR test only works with DNA, and labs first must convert the RNA to DNA to screen for COVID-19. For the test, RNA is isolated from a patient’s sample and combined with other ingredients, including short DNA sequences are known as primers, to transform the RNA into DNA.

RNA Reference Materials Are Useful for Standardizing COVID-19 Tests, Study Shows, NIST

(Credit: Giovanni Cancemi/Shutterstock) 

Topics: Biology, Condensed Matter Physics, Modern Physics, Quantum Mechanics

Note: After presenting my research proposal and acceptance by my committee, I've been taking a well-needed break from blogging. I'll post on and off until the New Year, which isn't too far off. Happy holidays!

In recent years, evidence has emerged that quantum physics seems to play a role in some of life’s fundamental processes. But just how it might do this is something of a mystery.

On the one hand, quantum phenomena are generally so delicate that they can only be observed when all other influences are damped – in other words in carefully controlled systems at temperatures close to absolute zero. By contrast, the conditions for life are generally complex, warm, and damp. Understanding this seemingly contradictory state of affairs is an important goal.

So physicists and biologists are keen to explore the boundaries of these very different regimes—life and quantum mechanics—to better understand where they might overlap.

Now Rainer Dumke at the Nanyang Technological University in Singapore and colleagues have created an exotic quantum state called entanglement using a superconducting qubit and a microscopic animal called a tardigrade. Along the way, the team has created the most extreme form of suspended animation ever recorded. “The tardigrade itself is shown to be entangled with the remaining subsystems,” they say.

To perform their entanglement experiment, Dumke and co cooled their tardigrade to below 10 millikelvins, almost to absolute zero, while reducing the pressure to a millionth of that in the atmosphere. In these conditions, no chemical reaction can occur so the tardigrade’s metabolism must have entirely halted stopped and the processes of life halted.

“This is to date the most extreme exposure to low temperatures and pressures that a tardigrade has been recorded to survive, clearly demonstrating that the state of cryptobiosis ultimately involves a suspension of all metabolic processes given that all chemical reactions would be prohibited with all its constituent molecules cooled to their ground states,” say the researchers.

In this condition, the tardigrade can be thought of as a purely dielectric element. Indeed, the researchers simulated their experiment by treating the tardigrade as a dielectric cube.

The experimental setup consisted of two superconducting capacitors, which when cooled can exist in a superposition of states called a qubit. They placed the tardigrade between the capacitor plates of one qubit so that it became an integral part of the capacitor. The team was then able to measure the effect of the tardigrade on the qubit’s properties.

How a Tardigrade "Micro Animal" Became Quantum Entangled with Superconducting Qubit, The Physics AriXiv Blog, Discovery Magazine

Visual Abstract

Topics: Biology, Biotechnology, COVID-19, Research

To advance a novel concept of debulking virus in the oral cavity, the primary site of viral replication, virus-trapping proteins CTB-ACE2 were expressed in chloroplasts and clinical-grade plant material was developed to meet FDA requirements. Chewing gum (2 g) containing plant cells expressed CTB-ACE2 up to 17.2 mg ACE2/g dry weight (11.7% leaf protein), have physical characteristics and taste/flavor like conventional gums, and no protein was lost during gum compression. CTB-ACE2 gum efficiently (>95%) inhibited entry of lentivirus spike or VSV-spike pseudovirus into Vero/CHO cells when quantified by luciferase or red fluorescence. Incubation of CTB-ACE2 microparticles reduced SARS-CoV-2 virus count in COVID-19 swab/saliva samples by >95% when evaluated by microbubbles (femtomolar concentration) or qPCR, demonstrating both virus trapping and blocking of cellular entry. COVID-19 saliva samples showed low or undetectable ACE2 activity when compared with healthy individuals (2,582 versus 50,126 ΔRFU; 27 versus 225 enzyme units), confirming greater susceptibility of infected patients for viral entry. CTB-ACE2 activity was completely inhibited by pre-incubation with SARS-CoV-2 receptor-binding domain, offering an explanation for reduced saliva ACE2 activity among COVID-19 patients. Chewing gum with virus-trapping proteins offers a generally affordable strategy to protect patients from most oral virus re-infections through debulking or minimizing transmission to others.

Debulking SARS-CoV-2 in saliva using angiotensin-converting enzyme 2 in chewing gum to decrease oral virus transmission and infection, Molecular Therapy: Cell.com

Henry Daniell, Smruti K. Nair, Nardana Esmaeili, Geetanjali Wakade, Naila Shahid, Prem Kumar Ganesan, Md Reyazul Islam, Ariel Shepley-McTaggart, Sheng Feng, Ebony N. Gary, Ali R. Ali, Manunya Nuth, Selene Nunez Cruz, Jevon Graham-Wooten, Stephen J. Streatfield, Ruben Montoya-Lopez, Paul Kaznica, Margaret Mawson, Brian J. Green, Robert Ricciardi, Michael Milone, Ronald N. Harty, Ping Wang, David B. Weiner, Kenneth B. Margulies, Ronald G. Collman

Credit: Getty Images

Topics: Biology, COVID-19, DNA, Research

Note: I have friends who thankfully survived infection now affected by this phenomenon. The article thus grabbed my attention.

SARS-CoV-2 appears to travel widely across the cerebral cortex

“Brain fog” is not a formal medical descriptor. But it aptly describes an inability to think clearly that can turn up in multiple sclerosis, cancer, or chronic fatigue. Recently, the condition has grabbed headlines because of reports that it afflicts those recovering from COVID-19.

COVID’s brain-related symptoms go beyond mere mental fuzziness. They range across a spectrum that encompasses headaches, anxiety, depression, hallucinations, and vivid dreams, not to mention well-known smell and taste anomalies. Strokes and seizures are also on the list. One study showed that more than 80 percent of COVID patients encountered neurological complications.

The mystery of how the virus enters and then inhabits the brain’s protected no-fly zone is under intensive investigation. At the 50th annual meeting of the Society for Neuroscience, or SFN (held in virtual form this month after a pandemic hiatus in 2020), a set of yet-to-be-published research reports chronicle aspects of the COVID-causing SARS-COV-2 virus’s full trek in the brain—from cell penetration to dispersion among brain regions, to disruption of neural functioning.

How COVID Might Sow Chaos in the Brain, Gary Stix, Scientific American

Topics: Biology, COVID-19, Education, Research

During the first year of the COVID-19 pandemic, the “[lab] leak” theory gained little traction. Sure, U.S. President Donald Trump suggested SARS-CoV-2 originated in a laboratory in Wuhan, China—and called it “the China virus”—but he never presented evidence, and few in the scientific community took him seriously. In fact, early in the pandemic, a group of prominent researchers dismissed lab-origin notions as “conspiracy theories” in a letter in The Lancet. A report from a World Health Organization (WHO) “joint mission,” which sent a scientific team to China in January to explore possible origins with Chinese colleagues, described a lab accident as “extremely unlikely.”

But this spring, views began to shift. Suddenly it seemed that the lab-leak hypothesis had been too blithely dismissed. In a widely read piece, fueled by a “smoking gun” quote from a Nobel laureate, a veteran science journalist accused scientists and the mainstream media of ignoring “substantial evidence” for the scenario. The head of WHO openly pushed back against the joint mission’s conclusion, and U.S. President Joe Biden ordered the intelligence community to reassess the lab-leak possibility. Eighteen scientists, including leaders in virology and evolutionary biology, signed a letter published in Science in May that called for a more balanced appraisal of the “laboratory incident” hypothesis.

Yet behind the clamor, little had changed. No breakthrough studies have been published. The highly anticipated U.S. intelligence review, delivered to Biden on 24 August, reached no firm conclusions but leaned toward the theory that the virus has a natural origin.

Fresh evidence that would resolve the question may not emerge anytime soon. China remains the best place to hunt for clues, but its relative openness to collaboration during the joint mission seems to have evaporated. Chinese officials have scoffed at calls from Biden and WHO Director-General Tedros Adhanom Ghebreyesus for an independent audit of key Wuhan labs, which some say should include an investigation of notebooks, computers, and freezers. Chinese vice health minister Zeng Yixin said such demands show “disrespect toward common sense and arrogance toward science.” In response to the increasing pressure, China has also blocked the “phase 2” studies outlined in the joint mission’s March report, which could reveal a natural jump between species.

Despite the impasse, many scientists say the existing evidence—including early epidemiological patterns, SARS-CoV-2’s genomic makeup, and a recent paper about animal markets in Wuhan—makes it far more probable that the virus, like many emerging pathogens, made a natural “zoonotic” jump from animals to humans.

Virologist Robert Garry of Tulane University finds it improbable that a Wuhan lab worker picked up SARS-CoV-2 from a bat and then brought it back to the city, sparking the pandemic. As the WIV study of people living near bat caves shows, the transmission of related bat coronaviruses occurs routinely. “Why would the virus first have infected a few dozen lab researchers?” he asks. The virus may also have moved from bats into other species before jumping to humans, as happened with SARS. But again, why would it have infected a lab worker first? “There are hundreds of millions of people who come in contact with wildlife.”

The earliest official announcement about the pandemic came on 31 December 2019, when Wuhan’s Municipal Health Commission reported a cluster of unexplained pneumonia cases linked to the city’s Huanan seafood market. The WHO report devotes much attention to details about Huanan and other Wuhan markets but also cautions that their role remains “unclear” because several early cases had no link to any market. But after reading the report, Andersen became more convinced that the Huanan market played a critical role.

One specific finding bolsters that case, Wang says. The report describes how scientists took many samples from floors, walls, and other surfaces at Wuhan markets and were able to culture two viruses isolated from Huanan. That shows the market was bursting with a virus, Wang says: “In my career, I have never been able to isolate a coronavirus from an environmental sample.”

The report also contained a major error: It claimed there were “no verified reports of live mammals being sold around 2019” at Huanan and other markets linked to early cases. A surprising study published in June by Zhou Zhao-Min of China West Normal University and colleagues challenged that view. It found nearly 50,000 animals from 38 species, most alive, for sale at 17 shops at Huanan and three other Wuhan markets between May 2017 and November 2019. (The researchers had surveyed the markets as part of a study of a tick-borne disease afflicting animals.)

Live animals can more easily transmit a respiratory virus than meat from a butchered one, and the animals included masked palm civets, the main species that transmitted SARS-CoV to humans, and raccoon dogs, which also naturally harbored that virus and have been infected with SARS-CoV-2 in lab experiments. Minks—a species farmed for fur that has acquired SARS-CoV-2 infections from humans in many countries— were also abundant. “None of the 17 shops posted an origin certificate or quarantine certificate, so all wildlife trade was fundamentally illegal,” Zhou and his colleagues wrote in their paper. (Zhou did not respond to emails from Science.)

Call of the Wild: Why many scientists say it’s unlikely that SARS-CoV-2 originated from a “lab leak,” Jon Cohen, Science Magazine

Topics: Astrobiology, Biology, Chemistry, Cosmology

The origin of life is one of the great unanswered questions in science. One piece of this puzzle is that life started on Earth 4.5 billion years ago, just a few hundred million years after the formation of the Solar System, and involved numerous critical molecular components. How did all these components come to be available so quickly?

One potential explanation is that the Earth was seeded from space with the building blocks for life. The idea is that space is filled with clouds of gas and dust that contain all the organic molecules necessary for life.

Indeed, astronomers have observed these buildings blocks in interstellar gas clouds. They can see amino acids, the precursors of proteins, and the machinery of life. They can also see the precursors of ribonucleotides, molecules that can store information in the form of DNA.

But there is another crucial component for life – molecules that can form membranes capable of encapsulating and protecting the molecules of life in compartments called protocells. On Earth, the membranes of all cells are made of molecules called phospholipids. But these have never been observed in space. Until now.

First evidence of cell membrane molecules in space, Physics arXiv blog, Astronomy

A computer simulation of the structure of the coronavirus SARS-CoV-2.Credit: Janet Iwasa, University of Utah

Topics: Biology, Biotechnology, COVID-19, DNA, Existentialism, Research

The coronavirus sports a luxurious sugar coat. “It’s striking,” thought Rommie Amaro, staring at her computer simulation of one of the trademark spike proteins of SARS-CoV-2, which stick out from the virus’s surface. It was swathed in sugar molecules, known as glycans.

“When you see it with all the glycans, it’s almost unrecognizable,” says Amaro, a computational biophysical chemist at the University of California, San Diego.

Many viruses have glycans covering their outer proteins, camouflaging them from the human immune system like a wolf in sheep’s clothing. But last year, Amaro’s laboratory group and collaborators created the most detailed visualization yet of this coat, based on structural and genetic data and rendered atom-by-atom by a supercomputer. On 22 March 2020, she posted the simulation to Twitter. Within an hour, one researcher asked in a comment: what was the naked, uncoated loop sticking out of the top of the protein?

Amaro had no idea. But ten minutes later, structural biologist Jason McLellan at the University of Texas at Austin chimed in: the uncoated loop was a receptor-binding domain (RBD), one of three sections of the spike that bind to receptors on human cells (see ‘A hidden spike’).

Source: Structural image from Lorenzo Casalino, Univ. California, San Diego (Ref. 1); Graphic: Nik Spencer/Nature

How the coronavirus infects cells — and why Delta is so dangerous, Megan Scudellari, Nature

A robotic hand with the AiFoam artificially innervated smart foam, which enables it to sense objects in proximity by detecting their electrical fields and also self-heals if it gets cut, is pictured at National University Singapore's Materials Sciences and Engineering lab in Singapore June 30, 2021. REUTERS/Travis Teo

Topics: Biology, Biotechnology, Materials Science, Polymer Science, Robotics

SINGAPORE, July 6 (Reuters) - Singapore researchers have developed a smart foam material that allows robots to sense nearby objects, and repairs itself when damaged, just like human skin.

Artificially innervated foam, or AiFoam, is a highly elastic polymer created by mixing fluoropolymer with a compound that lowers surface tension.

This allows the spongy material to fuse easily into one piece when cut, according to researchers at the National University of Singapore.

"There are many applications for such a material, especially in robotics and prosthetic devices, where robots need to be a lot more intelligent when working around humans," explained lead researcher Benjamin Tee.

To replicate the human sense of touch, the researchers infused the material with microscopic metal particles and added tiny electrodes underneath the surface of the foam.

Smart foam material gives robotic hand the ability to self-repair, Travis Teo, Lee Ying Shan, Reuters Science

Artist’s impression of UQ’s new quantum microscope in action. Credit: The University of Queensland

Topics: Biology, Biotechnology, Instrumentation, Quantum Mechanics, Quantum Optics

In a major scientific leap, University of Queensland researchers have created a quantum microscope that can reveal biological structures that would otherwise be impossible to see.

This paves the way for applications in biotechnology, and could extend far beyond this into areas ranging from navigation to medical imaging.

The microscope is powered by the science of quantum entanglement, an effect Einstein described as “spooky interactions at a distance.”

Professor Warwick Bowen, from UQ’s Quantum Optics Lab and the ARC Centre of Excellence for Engineered Quantum Systems (EQUS), said it was the first entanglement-based sensor with performance beyond the best possible existing technology.

“This breakthrough will spark all sorts of new technologies — from better navigation systems to better MRI machines, you name it,” Professor Bowen said.

“Entanglement is thought to lie at the heart of a quantum revolution. We’ve finally demonstrated that sensors that use it can supersede existing, non-quantum technology.

“This is exciting — it’s the first proof of the paradigm-changing potential of entanglement for sensing.”

Major Scientific Leap: Quantum Microscope Created That Can See the Impossible, University of Queensland

Liquidated3672 (2021), Theodore Lee Jones, CallMeTed.com.

Topics: Applied Physics, Biology, Microscopy, Molecules

A major challenge in cell biology remains to unravel is how cells control their biochemical reaction cycles. For instance, how do they regulate gene expression in response to stress? How does their metabolism change when resources are scarce? Control theory has proven useful in understanding how networks of chemical reactions can robustly tackle those and other tasks.¹ The essential ingredients in such approaches are chemical feedback loops that create control mechanisms similar to the circuits that regulate, for example, the temperature of a heating system, the humidity of an archive, or the pH of a fermentation tank.

Theories for the control of biochemical reactions have largely focused on homogeneous, well-stirred environments. However, macromolecules inside cells are often highly organized in space by specialized subunits called organelles. Some organelles, such as the cell nucleus, are bound by a membrane. By contrast, another class of organelles—biomolecular condensates—show the hallmark physical properties of liquid-like droplets, and they provide chemically distinct environments for biochemical reactions.^2–4

Such droplets can act as microreactors for biochemical reactions in a living cell (see figure 1). Their liquid nature sustains the fast diffusion of reactants while their specific composition gives rise to the partitioning of reactants in or out of the droplets. In general, the concentrations of reactants inside condensates differ from the concentrations outside. Those differences modify reaction fluxes, which, in turn, can dramatically affect reaction yield and other properties of chemical reactions. Just how such modified fluxes govern the biochemistry inside cells remains poorly understood.

Drops in Cells, Christoph Weber, Christoph Zechner, Physics Today

Topics: Biology, Planetary Science, Research, Tardigrades

They can survive temperatures close to absolute zero. They can withstand heat beyond the boiling point of water. They can shrug off the vacuum of space and doses of radiation that would be lethal to humans. Now, researchers have subjected tardigrades, microscopic creatures affectionately known as water bears, to impacts as fast as a flying bullet. And the animals survive them, too—but only up to a point. The test places new limits on their ability to survive impacts in space—and potentially seed life on other planets.

The research was inspired by a 2019 Israeli mission called Beresheet, which attempted to land on the Moon. The probe infamously included tardigrades on board that mission managers had not disclosed to the public, and the lander crashed with its passengers in tow, raising concerns about contamination. “I was very curious,” says Alejandra Traspas, a Ph.D. student at Queen Mary University of London who led the study. “I wanted to know if they were alive.”

Traspas and her supervisor, Mark Burchell, a planetary scientist at the University of Kent, wanted to find out whether tardigrades could survive such an impact—and they wanted to conduct their experiment ethically. So after feeding about 20 tardigrades moss and mineral water, they put them into hibernation, a so-called “tun” state in which their metabolism decreases to 0.1% of their normal activity, by freezing them for 48 hours.</em>

They then placed two to four at a time in a hollow nylon bullet and fired them at increasing speeds using a two-stage light gas gun, a tool in physics experiments that can achieve muzzle velocities far higher than any conventional gun. When shooting the bullets into a sand target several meters away, the researchers found the creatures could survive impacts up to about 900 meters per second (or about 3000 kilometers per hour), and momentary shock pressures up to a limit of 1.14 gigapascals (GPa), they report this month in Astrobiology. “Above [those speeds], they just mush,” Traspas says.</em>

Hardy water bears survive bullet impacts—up to a point, Jonathan O'Callaghan, Science Magazine

An unidentified flying object as seen in a declassified Department of Defense video, DoD

Topics: Aerodynamics, Applied Physics, Biology, Exoplanets, General Relativity, SETI

May 17, 2019- No, little green men aren't likely after the conquest of humanity. Boyd's piece for Phys.org highlights the reason why the Pentagon wants to identify UFOs: they're unidentified. If a warfighter on the ground or in the sky can't ID an object, that creates an issue since they don't know if it's friendly, adversarial, or neutral.

U.S. Navy pilots and sailors won't be considered crazy for reporting unidentified flying objects, under new rules meant to encourage them to keep track of what they see writes Iain Boyd for Phys.org.

Why is the Pentagon interested in UFOs? Intelligent Aerospace

The Pentagon refers to them as "transmedium vehicles," meaning vehicles moving through air, water, and space. Carolina Coastline breathlessly uses the term "defying the laws of physics." So I looked at what the paper might have meant. The objects apparently exceed the speed of sound without a sonic boom (signature of breaking the barrier). Even though this is reported by Popular Mechanics, they're quoting John Ratcliffe, whose name somehow sounds like a pejorative. Consider the source.

U.S. Navy F/A-18 flying faster than the speed of sound. The white cloud is formed by decreased air pressure and temperature around the tail of the aircraft.
ENSIGN JOHN GAY, U.S. NAVY

The speed of sound is 343 meters per second (761.21 miles per hour, 1,100 feet per second). Mach 1 is the speed of sound, Mach 2 is 1522.41 mph, Mach 3 is 2283.62 mph. NASA's X-43A scramjet sets the record at Mach 9.6 (7,000 mph), so, it's easy to see where Star Trek: The Next Generation got its Warp Speed analog from. The top speed of the F/A-18 is 1,190 mph. Pilots and astronauts under acceleration experience G Forces, and have suits to keep them from blacking out in a high-speed turn.

A Science Magazine article in 1967 reported the dimensions and speeds for the object were undeterminable. History.com reported an object exceeding 70 knots, or 80.5546 mph underwater (twice the speed of a nuclear submarine, so I can see the US Navy's concern). I found some of the descriptions on the site interesting:

5 UFO traits:

1. Anti-gravity lift (no visible means of propulsion), 2. Sudden and instantaneous acceleration (fast), 3. Hypersonic velocities without signatures (no sonic boom), 4. Low observability, or cloaking (not putting this on Romulans, or Klingons), 5. Trans-medium travel (air, water, space).

When I look at these factors, I don't get "little green men." First caveat: there are a lot of planets between us, and them with resources aplenty. Second caveat: any interest an alien intelligence might have in us is as caretakers of an experiment, or cattle. That's disturbing: ever see a rancher have conversations with a chicken, sow, or steer before slaughter?

My hypothesis (Occam's razor) - these are projections, but of a special kind:

For the first time, a team including scientists from the National Institute of Standards and Technology (NIST - 2016) have used neutron beams to create holograms of large solid objects, revealing details about their interiors in ways that ordinary laser light-based visual holograms cannot.

Holograms -- flat images that change depending on the viewer's perspective, giving the sense that they are three-dimensional objects -- owe their striking capability to what's called an interference pattern. All matter, such as neutrons and photons of light, has the ability to act like rippling waves with peaks and valleys. Like a water wave hitting a gap between the two rocks, a wave can split up and then re-combine to create information-rich interference patterns.

Move over, lasers: Scientists can now create holograms from neutrons, too, Science Daily

This of course doesn't explain the decades of observations, since holograms came into being in a 1948 paper by the Hungarian inventor Denis Gabor: “The purpose of this work is a new method for forming optical images in two stages. In the first stage, the object is lit using a coherent monochrome wave, and the diffraction pattern resulting from the interference of the secondary coherent wave coming from the object with the coherent background is recorded on the photographic plate. If the properly processed photographic plate is placed after its original position and only the coherent background is lit, an image of the object will appear behind it, in the original position.” Gabor won the Nobel Prize in 1971 for "his invention and development of the holographic method." Also: History of Holography

This is purely speculative. I have no intelligence other than what I've shared. It does in my mind, explain the physics-defying five traits described above. It does not explain the previous supposition of sightings since humans started recording history, or trying to hypothesize their sightings in antiquity. Solid objects flying at hypersonic speeds make sonic booms; projections - ball lightning, 3D laser, or solid neutron holograms - likely won't.

If these are projections (adversary, friendly, neutral), who is doing them, and why?

Continuous improvements in farming and biofuel production technology have helped establish ethanol as a low-carbon fuel.

Topics: Biology, Biofuels, Climate Change, Dark Side, Economics, Environment

The carbon footprint of corn ethanol shrunk by 23% between 2005 and 2019 as farmers and ethanol producers adopted new technologies and improved efficiency, according to a new analysis published in the academic journal Biofuels Bioproducts and Biorefining by scientists at the Department of Energy’s Argonne National Laboratory. By 2019, the researchers found, corn ethanol was reducing lifecycle greenhouse gas emissions by 44-52% compared to gasoline.

Since 2000, corn ethanol production in the United State has increased significantly – from 1.6 to 15 billion gallons – due to supportive biofuel policies. In its study, the Argonne laboratory conducted a retrospective analysis of the changes in U.S. corn ethanol greenhouse gas emission intensity, sometimes known as carbon intensity, over the 15 years from 2005 to 2019, showing a significant decrease of 23%.

The carbon footprint of corn ethanol shrunk by 23% between 2005 and 2019 as farmers and ethanol producers adopted new technologies and improved efficiency, according to a new analysis published in the academic journal Biofuels Bioproducts and Biorefining by scientists at the Department of Energy’s Argonne National Laboratory. By 2019, the researchers found, corn ethanol was reducing lifecycle greenhouse gas emissions by 44-52% compared to gasoline.

Since 2000, corn ethanol production in the United State has increased significantly – from 1.6 to 15 billion gallons – due to supportive biofuel policies. In its study, the Argonne laboratory conducted a retrospective analysis of the changes in U.S. corn ethanol greenhouse gas emission intensity, sometimes known as carbon intensity, over the 15 years from 2005 to 2019, showing a significant decrease of 23%.

This is due to several factors, the analysis explains. Corn grain yield has increased continuously, reaching 168 bushels/acre or a 15% increase while fertilizer inputs per acre have remained constant, resulting in decreased intensities of fertilizer inputs with a 7% and 18% reduction in nitrogen and potash use per bushel of corn grain harvested, respectively. The study also found a 14% reduction per bushel in farming energy use.

The analysis also found a 6.5% increase in ethanol yield, from 2.70 to 2.86 gal/bushel corn, and a 24% reduction in ethanol plant energy use, from 32 000 to 25 000 Btu/gal ethanol also helped reduce the carbon intensity.

“Our study shows that while the corn ethanol industry has experienced significant volume expansion, it has reduced the GHG intensity of corn ethanol through improved U.S. corn farming and ethanol biorefinery operations. Corn yield has increased, and chemical and energy use intensities of corn farming have decreased. In ethanol biorefineries, ethanol yield has increased, and energy use has decreased significantly,” according to the researchers. “Biofuels, including corn ethanol, can play a critical role in the U.S. desire for deep decarbonization of its economy.”

Bonus: I'm not sure Russian criminal elements can hack, or extort us with it.

Researchers add evidence to ethanol’s low-carbon benefits, Jacqui Fatka, Farm Progress

Residents of the Pairaisopolis favela in Sao Paolo wait for meal distribution in the economic crisis brought on by the pandemic. Credit: Alexandre Schneider Getty Images

Topics: Biology, COVID-19, Existentialism, Pandemic

Note: Many stories are coming out of Seychelles. It is the most vaccinated nation on earth that is seeing rising cases of the Coronavirus due to tourism by Indian elites. We're not going to solve this piecemeal, nor treating each other in our backward, moribund tribal "traditions." This fight is a long haul, and hubris can make it longer, and more painful.

To be in Brazil right now feels like being trapped in the middle of a chaotic battlefield, a 14-month-long siege, without anyone in charge on your side of the trenches. Totally surrounded by a lethal enemy that keeps getting closer to you and your family. This biological foe keeps morphing in a way that seems well adapted to infect everyone within reach, showing mercy neither for pregnant women nor for their newborn babies.

After 12 months of such brutal biological warfare, more than 390,000 Brazilians have perished; the number of fatalities climbed to more than 4,000 fatalities a day in early April, and the number of new cases per day edged above 100,000, filling hospitals to capacity with tens of thousands of terminally ill patients who occupy all available ICU beds in a country that has one of the largest national public health systems in the world and more hospitals than the U.S. Such a steady tsunami of severely sick patients has led to an unprecedented collapse of the entire country’s health system and the setting of yet another pair of world records in terms of both infected and deceased health professionals. On top of that, the country’s stock of medical equipment and the supplies required to intubate patients in need of respirators to survive are running at a historic low and may run out completely because the federal government simply failed in the process of replenishing the national stockpile several months ago.

This, in a nutshell, is the catastrophic and unprecedented hecatomb that Brazil found itself locked in by mid-April 2021. A devastating second wave of the pandemic began to engulf all five regions of the country back in early November 2020. It resulted, in part, from the premature and chaotic relaxation of social isolation measures that had helped at least some regions of the country contain the worst of the initial phase of the pandemic. It worsened because of the large public political rallies that preceded the two rounds of the 2020 national elections, generating a multitude of super spreader events all over the country. And the situation was exacerbated by Christmas and Carnival, the largest national festivity.

Brazil’s Pandemic Is a ‘Biological Fukushima’ That Threatens the Entire Planet, By Miguel Nicolelis, Scientific American

The mysterious object ‘Oumuamua passed through our solar system in 2017. Loeb has suggested it could have been sent by extraterrestrials. (Credit: European Southern Observatory/Kornmesser)

Topics: Astrobiology, Biology, Cosmology, SETI

Life, for all its complexities, has a simple commonality: It spreads. Plants, animals, and bacteria have colonized almost every nook and cranny of our world.

But why stop there? Some scientists speculate that biological matter may have proliferated across the cosmos itself, transported from planet to planet on wayward lumps of rock and ice. This idea is known as panspermia, and it carries a profound implication: Life on Earth may not have originated on our planet.

In theory, panspermia is fairly simple. Astronomers know that impacts from comets or asteroids on planets will sometimes eject debris with enough force to catapult rocks into space. Some of those space rocks will, in turn, crash into other worlds. A few rare meteorites on Earth are known to have come from Mars, likely in this fashion.

“You can imagine small astronauts sitting inside this rock, surviving the journey,” says Avi Loeb, an astrophysicist at Harvard University and director of the school’s Institute for Theory and Computation. “Microbes could potentially move from one planet to another, from Mars to Earth, from Earth to Venus.” (You may recognize Loeb’s name from his recent book Extraterrestrial: The First Sign of Intelligent Life Beyond Earth, which garnered headlines and criticism from astronomers for its claim that our solar system was recently visited by extraterrestrials.)</p>

Loeb has authored a number of papers probing the mechanics of panspermia, looking at, among other things, how the size and speed of space objects might affect their likelihood of transferring life. While Loeb still thinks it’s more likely that life originated on Earth, he says his work has failed to rule out the possibility that it came from somewhere else in space.

Did Life On Earth Come From Outer Space? Nathaniel Scharping, Discover Magazine